Aspirin

#VisualAbstract: Frequency of Intracranial Hemorrhage With Low-Dose Aspirin in Individuals Without Symptomatic Cardiovascular Disease

1. In this systematic review and meta-analysis, use of low-dose aspirin in patients without symptomatic cardiovascular disease was linked with an increased risk of intracranial hemorrhage (ICH). 2. Risk of ICH was greatest amongst those with low body mass, or Asian ethnicity. Evidence Rating Level: 1 (Excellent)       Study Rundown: The use Czytaj więcej…

Aspirin

Single dose aspirin prior to fecal immunochemical testing does not increase detection of advanced colorectal neoplasms

1. In this randomized controlled trial, single dose aspirin given two days prior to fecal immunochemical testing (FIT) did not increase test sensitivity for detection of colorectal cancer at 2 predefined cutoffs. 2. Study findings contrast with previous observational studies that showed increased sensitivity of FIT in users of low-dose Czytaj więcej…

Aspirin

Rivaroxaban likely reduces risk of recurrent stroke in specific subgroup of patients with embolic stroke of undetermined source

1. In this post-hoc analysis of data from the NAVIGATE-ESUS trial, which evaluated strategies to prevent recurrent stroke in patient of embolic stroke of undetermined source, use of rivaroxaban was linked with a lower risk of recurrent stroke compared to aspirin in patients with moderate to severe left atrial enlargement. Czytaj więcej…

Aspirin

Aspirin use associated with reduction in cardiovascular events but increase in bleeding risk

1. In this systematic review and meta-analysis, while aspirin use among patients without cardiovascular disease was associated with fewer adverse cardiovascular events, it was not associated with a reduction in all-cause mortality. 2. The use of aspirin in patients without cardiovascular disease was associated with increased risk of major bleeding. Evidence Czytaj więcej…

Aspirin

Aspirin alone likely safest antithrombotic therapy after bioprosthetic aortic valve replacement

1. Aspirin combined with warfarin was linked with increased bleeding but not less thromboembolism compared with aspirin alone after bioprosthetic aortic valve replacement. 2. Dual antiplatelet therapy showed a non-significant trend towards increased bleeding but no less thromboembolism compared with aspirin alone after bioprosthetic aortic valve replacement. Evidence Rating Level: Czytaj więcej…