Cardiology

Quick Take: Ultra-processed food intake and risk of cardiovascular disease

The consumption of ultra-processed food has increased substantially over the last several decades. These foods often have higher proportions of total and saturated fat, added sugar, energy density and salt, and lower proportions of fiber and vitamin density. Limited cross-sectional data has suggested associations with obesity, metabolic syndrome, functional gastrointestinal Czytaj więcej…

acid suppression

Quick Take: Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans

Proton pump inhibitors (PPIs) are widely used in the management of gastroesophageal reflux. However, several studies have demonstrated serious adverse events associated with PPI use including cardiovascular disease, acute kidney injury, chronic kidney disease, dementia, pneumonia, gastric cancer, Clostridium difficile infection, and increased risk of fracture. Recent evidence has also Czytaj więcej…

blood glucose

The VADT-F trial: major cardiovascular events or death are not reduced in diabetics with intensive glucose control therapy

1. In a 15-year observational cohort study of type 2 diabetics treated with intensive compared to standard glucose control therapy the risk of major cardiovascular event or death was similar between both treatment groups. 2. There was no reported difference in health-related quality of life scores between the intensive and Czytaj więcej…

Cardiology

Neladenoson does not increase exercise capacity for heart failure with preserved ejection fraction

1. In this randomized controlled trial, heart failure with preserved ejection fraction (HFpEF) patients did not have improved exercise capacity with neladenoson versus placebo. 2. There were no changes in activity intensity, NT-proBNP level, high-sensitivity troponin T level, or quality of life with neladenoson. Evidence Rating Level: 1 (Excellent) Study Czytaj więcej…

Cardiology

Unrecognized myocardial infarctions associated with embolic cerebral infarctions of undetermined source

1. In this cross-sectional cohort study of older adults in Iceland, MRI findings of myocardial infarction was associated with coincident MRI findings of cerebral infarction. 2. Patients with embolic patterns of cerebral infarction, without a clear source, had a higher likelihood of unrecognized myocardial infarction diagnosed by MRI. Evidence Rating Czytaj więcej…

antiplatelet

Quick Take: Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART)

Patients with a history of occlusive vascular disease who are on antithrombotic therapy are at an increased risk of intracerebral hemorrhage. Generally, antithrombotic therapy is discontinued after intracerebral hemorrhage in these patients. However, no published randomized trials have studied the long-term safety of antithrombotic therapy in survivors of intracerebral hemorrhage. Czytaj więcej…

antibiotic eluting envelope

The WRAP-IT trial: antibiotic-eluting envelope covering implanted cardiac devices lowers incidence of major injections

1. An absorbable, antibiotic-eluting envelope covering cardiac implantable electronic devices (CIEDs) significantly lowered the incidence of major infection within 12 months of the procedure compared to devices without the covering. 2. Procedure- or system-related complications occurring within 12 months of device implantation did not differ between the groups. Evidence Rating Czytaj więcej…