antibiotic eluting envelope

The WRAP-IT trial: antibiotic-eluting envelope covering implanted cardiac devices lowers incidence of major injections

1. An absorbable, antibiotic-eluting envelope covering cardiac implantable electronic devices (CIEDs) significantly lowered the incidence of major infection within 12 months of the procedure compared to devices without the covering. 2. Procedure- or system-related complications occurring within 12 months of device implantation did not differ between the groups. Evidence Rating Czytaj więcej…

Cardiology

Unrecognized obstructive sleep apnea increases risk of postoperative cardiovascular events

1. In this prospective cohort study, severe but not moderate, unrecognized obstructive sleep apnea was associated with increased postoperative cardiovascular events in patients undergoing major non-cardiac surgery. 2. Mean cumulative oxyhemoglobin desaturation less than 80% during the first 3 postoperative nights was longer in those with cardiovascular complications. Evidence Rating Czytaj więcej…

altepase

The EXTEND trial: neurological deficits decreased with thrombolysis up to 9 hours after stroke onset

1. Patients presenting between 4.5 and 9 hours after stroke onset with viable brain tissue who received thrombolytic therapy had better neurological outcomes compared to those receiving placebo. 2. Symptomatic intracranial hemorrhage occurred in a higher number of patients in the thrombolysis group compared to placebo group. Evidence Rating Level: Czytaj więcej…

Cardiology

Cardiovascular outcomes of dialysis patients using phosphate binders with or without calcium

1. In this observational cohort study of patients with end-stage renal disease (ESRD) undergoing hemodialysis, there was no observed difference in cardiovascular events for patients receiving calcium-containing or calcium-free phosphate binders. 2. There was no difference in outcomes observed in pre-specified subgroup analysis based on sex or age group. Evidence Czytaj więcej…