Amyloidosis

Patisiran therapy reduces ventricular myocardial strain in hereditary transthyretin amyloidosis

1. Use of patisiran, an RNA interference therapy, in patients with hereditary transthyretin (hATTR) cardiac amyloidosis was linked to reduced left ventricular global longitudinal strain (LVGLS) compared with placebo. 2. The therapy-associated reduction in ventricular myocardial strain was greatest for the basal region. The mid and apical regions of the Czytaj więcej…

aortic stenosis

The PARTNER 3 Trial: TAVR with balloon-expandable valves has favorable post-surgical outcomes among low-risk patients with severe aortic stenosis

1. This randomized control trial compared post-surgical outcomes between transcatheter aortic-valve replacement (TAVR) with balloon-expandable valves or surgical valve replacement in low- risk surgical patients, finding that patients randomized to receive TAVR had significantly lower rates of composite death, stroke or rehospitalization after one year. 2. Patients randomized to the Czytaj więcej…

atrial fibrillation

Direct oral anticoagulants for atrial fibrillation in patients with mitral stenosis

1. In this retrospective observational study, direct oral anticoagulant use for atrial fibrillation in patients with mitral stenosis was linked with decreased mortality and fewer thromboembolic events compared to warfarin.  2. There was also a non-significant trend towards fewer episodes of intracranial hemorrhage with direct oral anticoagulant use. Evidence Rating Czytaj więcej…

Cardiology

Quick Take: Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results

Cervical artery dissection is a common cause of ischemic stroke in young patients. Whether antiplatelet (AP) therapy or anticoagulation (AC) therapy is more effective at preventing recurrent stroke after dissection is unknown. In 2015, data from the Cervical Artery Dissection in Stroke Study (CADISS) trial showed no difference in event Czytaj więcej…

Cardiology

Patient-centered transitional care services unlikely to benefit hospitalized heart failure patients

1. In this randomized controlled trial, patient-centered transitional care services did not improve a composite of clinical outcomes in hospitalized heart failure patients. 2. Patients who received transitional care had improved discharge readiness scores. Evidence Rating Level: 1 (Excellent) Study Rundown: Heart failure (HF) is a leading cause of hospitalizations Czytaj więcej…