chronic disease

The SENSCIS trial: nintedanib slows declines in FVC in patients with interstitial lung disease caused by systemic sclerosis

1. The SENSCIS trial, a randomized control trial studying the efficacy of nintedanib, an intracellular tyrosine kinase inhibitor, versus placebo on respiratory function among patients with interstitial lung disease mediated by systemic sclerosis, found a slower forced vital capacity (FVC) decline in patients treated with nintedanib. 2. There were no Czytaj więcej…

adjustable gastric banding (AGB)

Quick Take: Fracture risk after Roux-en-Y gastric bypass adjustable gastric banding among Medicare beneficiaries

Roux-en-Y gastric bypass (RYGB) is associated with significant bone loss and may increase fracture risk as a result. This is in contrast to other bariatric procedures, such as adjustable gastric banding (AGB), which has not been found to confer the same fracture risk to date. In this retrospective cohort study, Czytaj więcej…

chronic disease

Quick Take: Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP)

Corticosteroids are frequently used in the treatment of acute chronic obstructive pulmonary disease (COPD) exacerbations. However, the use of systemic corticosteroids is not without its risks. As such, strategies to limit systemic corticosteroid exposure are needed. In this multicenter randomized controlled trial, 318 patients age 40 years and older with Czytaj więcej…

antibiotic eluting envelope

The WRAP-IT trial: antibiotic-eluting envelope covering implanted cardiac devices lowers incidence of major injections

1. An absorbable, antibiotic-eluting envelope covering cardiac implantable electronic devices (CIEDs) significantly lowered the incidence of major infection within 12 months of the procedure compared to devices without the covering. 2. Procedure- or system-related complications occurring within 12 months of device implantation did not differ between the groups. Evidence Rating Czytaj więcej…

amyotrophic lateral sclerosis (ALS)

Quick Take: Amyotrophic Lateral Sclerosis versus Multifocal Motor Neuropathy: Utility of MR Neurography

Both multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) affect the peripheral nervous system and present with palsies. Differentiating between these two diseases is important from a prognostic perspective, as MMN should be treated as early as possible with immunomodulatory therapy, while ALS is not currently treatable. Magnetic resonance Czytaj więcej…

Adolescent health

Young drivers with ADHD linked with higher rates of crashes and violations

1. Adolescents with a diagnosis of attention-deficit/hyperactivity disorder (ADHD) experienced higher rates of crashes compared to adolescents without ADHD, including at-fault, single-vehicle, injury, and alcohol-related crashes. 2. Rates of traffic and moving violations were also higher among adolescents with ADHD, and differences in crash and violation rates were more pronounced Czytaj więcej…