blood donor

Blood transfusions from female, previously pregnant, or sex-discordant donors do not increase mortality

1. In this large retrospective cohort, there were no increases in mortality from red blood cell transfusions from female, previously pregnant, or sex-discordant donors. Evidence Rating Level: 2 (Good) Study Rundown: Recently, a few studies have suggested that blood donation from female donors, especially to male recipients, may result increased Czytaj więcej…

chronic disease

High rates of oophorectomy for benign ovarian neoplasms in pediatric population

1. In this multicenter retrospective cohort study, pediatric patients with an ovarian neoplasm had high rates of oophorectomy despite low rates of malignancy. Premenarchal status, clinical symptoms on presentation, concerning features on imaging, and having the surgery performed by an adult gynecologist or pediatric surgeon were all associated with increased Czytaj więcej…

Cancer

Quick Take: Treatment and Long-Term Clinical Outcomes of Incidental Pulmonary Embolism in Patients With Cancer

Venous thromboembolism (VTE) is a common complication in patients with cancer. Often, VTEs are incidentally detected on imaging studies undertaken for cancer staging or evaluation of treatment response. Current guidelines recommend that the same anticoagulant treatment be used for both incidental pulmonary embolism (PE) and symptomatic PE in patients with Czytaj więcej…

benzodiazepine

Quick Take: Association between incidence exposure to benzodiazepines in early pregnancy and risk of spontaneous abortion

Previous studies have shown that benzodiazepine use in early pregnancy is associated with spontaneous abortion (SA). The association between specific benzodiazepines and the risk of SA, however, has not been investigated. In this nested case-control study based in Montreal, Quebec, Canada, cases defined as any pregnancy loss between the beginning Czytaj więcej…

alpelisib

The SOLAR-1 trial: alpelisib prolongs progression free survival in PIK3CA-mutated, HR-positive, HER2-negative breast cancer patients

1. Treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)–negative breast cancer patients who have a mutated phosphatidylinositol 3-kinase (PIK3) with the PIK3 inhibitor alpelisib, in addition to fulvestrant, increased progression free survival compared to treatment with fulvestrant alone. 2. The most common severe adverse effects in Czytaj więcej…

chronic disease

Quick Take: Preterm birth and risk of chronic kidney disease from childhood into mid-adulthood: national cohort study

Fetal nephrogenesis is most significant in the third trimester of pregnancy, and is interrupted by preterm birth before 37 weeks of gestation, resulting in lower nephron numbers and the development of hypertension and progressive renal disease later in life. While low birth weight has been associated with chronic kidney disease Czytaj więcej…

chronic disease

Quick Take: Association of socioeconomic status and brain injury with neurodevelopmental outcomes of very preterm children

Preterm birth remains a leading cause of lifelong neurodevelopmental disability. While the effect of brain injury on neurodevelopmental disability has been studied extensively, far less is known with respect to the role of environments and experiences in moderating these associations. In this prospective cohort study, preterm neonates (24-32 weeks’ gestation) Czytaj więcej…

bleeding during pregnancy

The PRISM trial: Progesterone therapy does not alter birth outcomes in women with early pregnancy bleeding

1. Women with early pregnancy bleeding administered progesterone experienced similar rates of live births occurring after 34 weeks’ gestation as women treated with placebo. 2. Subgroup analysis was generally inconclusive, though many subgroups had risk ratios approaching significance supporting progesterone use. Evidence Rating Level: 1 (Excellent)   Study Rundown: Miscarriages are Czytaj więcej…