blood donor

Blood transfusions from female, previously pregnant, or sex-discordant donors do not increase mortality

1. In this large retrospective cohort, there were no increases in mortality from red blood cell transfusions from female, previously pregnant, or sex-discordant donors. Evidence Rating Level: 2 (Good) Study Rundown: Recently, a few studies have suggested that blood donation from female donors, especially to male recipients, may result increased Czytaj więcej…

Cardiology

Quick Take: Ultra-processed food intake and risk of cardiovascular disease

The consumption of ultra-processed food has increased substantially over the last several decades. These foods often have higher proportions of total and saturated fat, added sugar, energy density and salt, and lower proportions of fiber and vitamin density. Limited cross-sectional data has suggested associations with obesity, metabolic syndrome, functional gastrointestinal Czytaj więcej…

acid suppression

Quick Take: Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans

Proton pump inhibitors (PPIs) are widely used in the management of gastroesophageal reflux. However, several studies have demonstrated serious adverse events associated with PPI use including cardiovascular disease, acute kidney injury, chronic kidney disease, dementia, pneumonia, gastric cancer, Clostridium difficile infection, and increased risk of fracture. Recent evidence has also Czytaj więcej…

chronic disease

Quick Take: Low rates of specialized cancer consultation and cancer-directed therapy for noncurable pancreatic adenocarcinoma

Eighty percent of patients with advanced or metastatic pancreatic adenocarcinoma are not candidates for surgical resection and require noncurative therapy, including multi-agent chemotherapy regimens, radiation therapy, nerve blocks and other symptomatic relief modalities. Despite having established benefits for patients, a large proportion of pancreatic adenocarcinoma patients are unable to access Czytaj więcej…

blood glucose

The VADT-F trial: major cardiovascular events or death are not reduced in diabetics with intensive glucose control therapy

1. In a 15-year observational cohort study of type 2 diabetics treated with intensive compared to standard glucose control therapy the risk of major cardiovascular event or death was similar between both treatment groups. 2. There was no reported difference in health-related quality of life scores between the intensive and Czytaj więcej…