Aspirin

#VisualAbstract: Frequency of Intracranial Hemorrhage With Low-Dose Aspirin in Individuals Without Symptomatic Cardiovascular Disease

1. In this systematic review and meta-analysis, use of low-dose aspirin in patients without symptomatic cardiovascular disease was linked with an increased risk of intracranial hemorrhage (ICH). 2. Risk of ICH was greatest amongst those with low body mass, or Asian ethnicity. Evidence Rating Level: 1 (Excellent)       Study Rundown: The use Czytaj więcej…

cardiovascular events

#VisualAbstract: Association of Unrecognized Obstructive Sleep Apnea With Postoperative Cardiovascular Events in Patients Undergoing Major Noncardiac Surgery

1. In this prospective cohort study, severe but not moderate, unrecognized obstructive sleep apnea was associated with increased postoperative cardiovascular events in patients undergoing major non-cardiac surgery. 2. Mean cumulative oxyhemoglobin desaturation less than 80% during the first 3 postoperative nights was longer in those with cardiovascular complications. Evidence Rating Czytaj więcej…

bleeding during pregnancy

#VisualAbstract: A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy

1. Women with early pregnancy bleeding administered progesterone experienced similar rates of live births occurring after 34 weeks’ gestation as women treated with placebo. 2. Subgroup analysis was generally inconclusive, though many subgroups had risk ratios approaching significance supporting progesterone use. Evidence Rating Level: 1 (Excellent)   Study Rundown: Miscarriages are not Czytaj więcej…

cardiac arrest

#VisualAbstract: Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest

1. In this randomized controlled trial, intra-cardiac arrest, trans-nasal evaporative cooling did not improve survival with good neurologic outcome at 90 days compared to standard systemic cooling in the ICU. 2. The time to core target temperature was shorter in the intra-nasal cooling group. Evidence Rating Level: 1 (Excellent) Study Czytaj więcej…

dual anti-platelet therapy (DAPT)

#VisualAbstract: Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers

1. A monoclonal antibody fragment to ticagrelor, PB2452, increased platelet function significantly in healthy patients given the oral P2Y12 inhibitor ticagrelor. 2. Adverse effects were mainly limited to the infusion site, with limited systemic events. Evidence Rating Level: 1 (Excellent)       Study Rundown: Antiplatelet therapy is used extensively for prevention of cardiovascular occlusive Czytaj więcej…