Osteoarthritis

#VisualAbstract: Association of Tramadol With All-Cause Mortality Among Patients With Osteoarthritis

1. In this retrospective cohort of patients with osteoarthritis, tramadol had a significantly higher risk of mortality over 1 year compared to NSAIDs, though there were many confounding factors precluding determination of a causal relationship. 2. No differences in mortality were found when comparing tramadol and codeine. Evidence Rating Level: Czytaj więcej…

bag-mask ventilation

#VisualAbstract: Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults

1. For intensive care unit (ICU) patients undergoing tracheal intubation, bag-mask ventilation between induction and laryngoscopy resulted in less hypoxia during the procedure. 2. No difference in aspiration was reported for patients in the groups undergoing intubation with or without bag-mask ventilation. Evidence Rating Level: 1 (Excellent)       Study Rundown: A significant Czytaj więcej…

Depression

#VisualAbstract: Effect of Integrated Behavioral Weight Loss Treatment and Problem-Solving Therapy on Body Mass Index and Depressive Symptoms Among Patients With Obesity and Depression

1. In this randomized controlled trial, integrated behavioral weight loss treatment, problem-solving therapy, and as needed antidepressant treatment led to a modest reduction in depression symptoms and weight loss at 12 months compared to care as usual. 2. The intervention was successful in non-Hispanic white patients, women, and those older Czytaj więcej…

lymphadenectomy

#VisualAbstract: A Randomized Trial of Lymphadenectomy in Patients with Advanced Ovarian Neoplasms

2 Minute Medicine’s The Classics in Medicine: Summaries of the Landmark Trials is available now in paperback and e-book editions. This text summarizes the key trials in: General Medicine and Chronic Disease, Cardiology, Critical and Emergent Care, Endocrinology, Gastroenterology, Hematology and Oncology, Imaging, Infectious Disease, Nephrology, Neurology, Pediatrics, Psychiatry, Pulmonology, and Czytaj więcej…

heart failure

#VisualAbstract: Effect of Patient-Centered Transitional Care Services on Clinical Outcomes in Patients Hospitalized for Heart Failure

1. In this randomized controlled trial, patient-centered transitional care services did not improve a composite of clinical outcomes in hospitalized heart failure patients. 2. Patients who received transitional care had improved discharge readiness scores. Evidence Rating Level: 1 (Excellent) Study Rundown: Heart failure (HF) is a leading cause of hospitalizations in Czytaj więcej…

IBD

#VisualAbstract: Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease

1. In this case-control study of patients of European ancestry with inflammatory bowel disease (IBD), variants in NUDT15 were associated with an increased risk of thiopurine-induced myelosuppression (TIM). 2. There were no sex-based differences in these genetic variants nor were there any differences based on IBD type. Evidence Rating Level: 2 (Good) Czytaj więcej…

dialysis

#VisualAbstract: Intravenous Iron in Patients Undergoing Maintenance Hemodialysis

1. Patients undergoing maintenance hemodialysis experienced fewer serious adverse events if treated proactively with high-dose intravenous iron sucrose compared to patients reactively treated with low-dose iron sucrose. 2. Higher doses of erythropoiesis-stimulating agents were utilized more in the low-dose iron group compared to the high-dose group. Evidence Rating Level: 1 Czytaj więcej…

Sickle Cell Anemia

#VisualAbstract: Association of Matched Sibling Donor Hematopoietic Stem Cell Transplantation With Transcranial Doppler Velocities in Children With Sickle Cell Anemia

1. In this nonrandomized controlled intervention study, matched sibling donor stem cell transplantation (MSD-HSCT) was associated with lower transcranial doppler velocities (TCDs) at 1 year compared to chronic transfusions. 2. MSD-HSCT was also associated with changes in highest TCDs at 3 years, normalization rate at 1 year, and ferritin levels Czytaj więcej…